Tadalafil is metabolized by the liver and excreted by the kidneys. In individuals with severe kidney or liver diseases, the medication’s clearance from the body may be delayed, leading to higher drug levels in the bloodstream. This can increase the risk of side effects and reduce the medication’s ability to work effectively. Adjusting the dosage may be necessary for those with mild liver or kidney impairment, but severe cases could make Vidalista 2.5 ineffective.
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